Rennie Kendrick

Obsessive-compulsive disorder (OCD) is a prevalent and debilitating psychiatric disorder that affects 1-2% of the population. Alterations in neural activity in several brain regions have been tied to OCD symptoms, but the underlying molecular and cellular mechanisms in the human brain are unresolved. This level of understanding is necessary to develop targeted pharmaceutical treatments, as well as to refine existing interventions. In collaboration with Dr. Scott Owen and Dr. Scott Linderman, I will combine multidimensional computational methods with cutting-edge experimental interventions inliving, neurosurgically-resected human brain tissue to unravel cellular and molecular mechanisms of OCD in the human brain.